PREPARATION OF 6-FLUOROBENZISOTHIAZOLES VIA A REGIOSELECTIVE NUCLEOPHILIC AROMATIC-SUBSTITUTION REACTION

被引：15

作者：

FINK, DM

STRUPCZEWSKI, JT

机构：

[1] Chemical Research Department, Neuroscience Strategic Business Unit, Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ 08876

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 41期

关键词：

D O I：

10.1016/0040-4039(93)88095-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient three step procedure for the preparation of 6-fluoro- 1,2-benzisothiazoles is described. The key step is a regioselective nucleophilic aromatic substitution reaction in which the carbonyl group of a ketone or aldehyde directs nucleophilic displacement to the ortho position in preference to the para position.

引用

页码：6525 / 6528

页数：4

共 9 条

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