TITANIUM-INDUCED ZIPPER REACTIONS

被引：31

作者：

FURSTNER, A

PTOCK, A

WEINTRITT, H

GODDARD, R

KRUGER, C

机构：

[1] Max-Planck-Institut für Kohlenforschung, Mülheim, D-45470

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 06期

关键词：

INDOLES; MCMURRY REACTIONS; TITANIUM COMPOUNDS;

D O I：

10.1002/anie.199506781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Remarkably high chemo‐ and regioselectivity was found in the intramolecular one‐pot McMurray‐type reaction between ketone and amide carbonyl groups. A simple preparative method is used by which the active low‐valent titanium species is formed selectively at the site of the reductive coupling. For example, compound 2 is formed from 1 in 86% yield by a zipper‐like series of carbonyl couplings. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：678 / 681

页数：4

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