THE EXPRESSION OF A NOVEL RECEPTOR-TYPE TYROSINE PHOSPHATASE SUGGESTS A ROLE IN MORPHOGENESIS AND PLASTICITY OF THE NERVOUS-SYSTEM

被引：98

作者：

CANOLL, PD ^{[1
]}

BARNEA, G ^{[1
]}

LEVY, JB ^{[1
]}

SAP, J ^{[1
]}

EHRLICH, M ^{[1
]}

SILVENNOINEN, O ^{[1
]}

SCHLESSINGER, J ^{[1
]}

MUSACCHIO, JM ^{[1
]}

机构：

[1] NYU MED CTR,DEPT PHARMACOL,550 1ST AVE,NEW YORK,NY 10016

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1993年 / 75卷 / 02期

关键词：

RADIAL GLIA; PLASTICITY; FIBRONECTIN; BERGMANN GLIA; TYROSINE PHOSPHATASE; AXONAL GUIDANCE; VENTRICULAR ZONE; NEURONAL MIGRATION;

D O I：

10.1016/0165-3806(93)90035-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is highly expressed in radial glia and other forms of glial cells that play an important role during development. The immunoreactivity localizes to the radial processes of these cells, which act as guides during neuronal migration and axonal elongation. The pattern of RPTP-beta expression changes with the progression of glial cell differentiation. In the adult, high levels of RPTP-beta are seen in regions of the brain where there is continued neurogenesis and neurite outgrowth. The spatial and temporal patterns of RPTP-beta expression suggest that this receptor phosphatase plays a role in morphogenesis and plasticity of the nervous system.

引用

页码：293 / 298

页数：6

共 27 条

[1] IDENTIFICATION OF A CARBONIC ANHYDRASE-LIKE DOMAIN IN THE EXTRACELLULAR REGION OF RPTP-GAMMA DEFINES A NEW SUBFAMILY OF RECEPTOR TYROSINE PHOSPHATASES [J].

BARNEA, G ;

SILVENNOINEN, O ;

SHAANAN, B ;

HONEGGER, AM ;

CANOLL, PD ;

DEUSTACHIO, P ;

MORSE, B ;

LEVY, JB ;

LAFORGIA, S ;

HUEBNER, K ;

MUSACCHIO, JM ;

SAP, J ;

SCHLESSINGER, J .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1497-1506

[2] THE LEUKOCYTE COMMON ANTIGEN (CD45) - A PUTATIVE RECEPTOR-LINKED PROTEIN TYROSINE PHOSPHATASE [J].

CHARBONNEAU, H ;

TONKS, NK ;

WALSH, KA ;

FISCHER, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7182-7186

[3] GLIAL INFLUENCES ON AXONAL GROWTH IN THE PRIMARY OLFACTORY SYSTEM [J].

DOUCETTE, R .

GLIA, 1990, 3 (06) :433-449

[4] IMMUNOHISTOCHEMICAL DEMONSTRATION OF AN ORGANIZED CYTOARCHITECTURE OF THE RADIAL GLIA IN THE CNS OF THE EMBRYONIC MOUSE [J].

DUPOUEY, P ;

BENJELLOUN, S ;

GOMES, D .

DEVELOPMENTAL NEUROSCIENCE, 1985, 7 (02) :81-93

[5]

EDMONDSON JC, 1987, J NEUROSCI, V7, P1928

[6] ORGANIZATION OF RADIAL GLIA AND RELATED CELLS IN THE DEVELOPING MURINE CNS - AN ANALYSIS BASED UPON A NEW MONOCLONAL-ANTIBODY MARKER [J].

EDWARDS, MA ;

YAMAMOTO, M ;

CAVINESS, VS .

NEUROSCIENCE, 1990, 36 (01) :121-144

[7] FINE-STRUCTURAL RELATIONSHIPS BETWEEN NEURITES AND RADIAL GLIAL PROCESSES IN DEVELOPING MOUSE SPINAL-CORD [J].

HENRIKSON, CK ;

VAUGHN, JE .

JOURNAL OF NEUROCYTOLOGY, 1974, 3 (06) :659-675

[8]

KRUEGER NX, 1992, P NATL ACAD SCI USA, V89, P7414

[9]

KUWABARA T, 1975, INVEST OPHTH VISUAL, V14, P732

[10]

LEVY JB, 1993, J BIOL CHEM, V268, P10573

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