SEQUENCES OF MEMORY-GUIDED SACCADES IN PARKINSONS-DISEASE

被引：47

作者：

VERMERSCH, AI

RIVAUD, S

VIDAILHET, M

BONNET, AM

GAYMARD, B

AGID, Y

PIERROTDESEILLIGNY, C

机构：

[1] HOP LA PITIE SALPETRIERE,SERV NEUROL,F-75651 PARIS 13,FRANCE

[2] HOP LA PITIE SALPETRIERE,INSERM,U289,F-75651 PARIS 13,FRANCE

来源：

ANNALS OF NEUROLOGY | 1994年 / 35卷 / 04期

关键词：

D O I：

10.1002/ana.410350419

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., ''on'') and without (i.e., ''off'') levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the ''off'' state, but significantly improved during the ''on'' period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.

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页码：487 / 490

页数：4

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