COUPLED CYCLODEXTRIN APPENDING IMIDAZOLE AS AN ENZYME MODEL

被引：25

作者：

AKIIKE, T ^{[1
]}

NAGANO, Y ^{[1
]}

YAMAMOTO, Y ^{[1
]}

NAKAMURA, A ^{[1
]}

IKEDA, H ^{[1
]}

UENO, A ^{[1
]}

TODA, F ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, FAC BIOSCI & BIOTECHNOL, DEPT BIOENGN, MIDORI KU, YOKOHAMA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 06期

关键词：

D O I：

10.1246/cl.1994.1089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel imidazole-appended coupled beta-cyclodextrin (6) was prepared by the condensation of 6-deoxy-6-(L-histidylamino)-beta-cyclodextrin and 6(carboxymethylthio)-6-deoxy-beta-cyclodextrin with dicyclohexylcarbodiimide. The enzyme-like activities of 6 were studied by measuring the rates for the hydrolysis reaction of some kinds of p-nitrophenyl alkanoates (C2, C3, C6, and C12). 6 showed large acceleration ability and substrate specificity for only p-nitrophenyl C6 ester.

引用

页码：1089 / 1092

页数：4

共 13 条

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