未找到相关数据
IDENTIFICATION AND FUNCTIONAL EXPRESSION OF A RECEPTOR SELECTIVELY RECOGNIZING PARATHYROID-HORMONE, THE PTH2 RECEPTOR
被引：306
作者：
USDIN, TB
GRUBER, C
BONNER, TI
机构：
[1] Laboratory of Cell Biology, NIMH, Bldg. 36, Bethesda, MD 20892-4090
关键词：
D O I：
10.1074/jbc.270.26.15455
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
引用
收藏
页码：15455 / 15458
页数：4
相关论文