AUTOXIDATION OF ASCORBIC-ACID CATALYZED BY A SEMISYNTHETIC ENZYME

被引：12

作者：

GERMANAS, JP ^{[1
]}

KAISER, ET ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,BIOORGAN CHEM & BIOCHEM,NEW YORK,NY 10021

来源：

BIOPOLYMERS | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1002/bip.360290107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The semisyntehtic enzyme 6 was prepared by alkylation of the cysteine‐25 sulfhydryl group of papain with the bipyridine 5 and was shown to stoichiometrically bind copper ion; 7 catalyzed the autoxidation of ascorbic acid derivatives with saturation kinetics approximately 20‐fold faster than a model system using 3‐Cu(II). Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：39 / 43

页数：5

共 17 条

[1]

ARNON R, 1970, METHOD ENZYMOL, V19, P227

[2]

BURSTEIN SR, 1976, IRON COPPER PROTEINS, P472

[3]

CHIA PSK, 1966, AUST J CHEM, P1835

[4]

EMDE H, 1982, SYNTHESIS-STUTTGART, P1

[5] METHYL 4,6-O-BENZYLIDENE-ALPHA AND BETA-D-GLUCOSIDES [J].

EVANS, ME .

CARBOHYDRATE RESEARCH, 1972, 21 (03) :473-&

[6]

FERSHT A, 1985, ENZYME STRUCTURE MEC, P183

[7]

FUNK MO, 1979, INT J PEPT PROT RES, V13, P296

[8]

GAMPP H, 1981, MET IONS BIOL SYST, V12, P133

[9] TOTAL SYNTHESIS OF (R)-GLYCEROL ACETONIDE AND THE ANTIEPILEPTIC AND HYPOTENSIVE DRUG "(-)-GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID (GABOB) - USE OF VITAMIN-C AS A CHIRAL STARTING MATERIAL [J].

JUNG, ME ;

SHAW, TJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (20) :6304-6311

[10] CATALYTIC ACTIVITY OF ENZYMES ALTERED AT THEIR ACTIVE-SITES [J].

KAISER, ET .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1988, 27 (07) :913-922

← 1 2 →