A GENE IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II REGION CONTROLLING THE CLASS-I ANTIGEN PRESENTATION PATHWAY

被引：664

作者：

SPIES, T

BRESNAHAN, M

BAHRAM, S

ARNOLD, D

BLANCK, G

MELLINS, E

PIOUS, D

DEMARS, R

机构：

[1] UNIV S FLORIDA,COLL MED,DEPT BIOCHEM & MOLEC BIOL,TAMPA,FL 33612

[2] UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195

[3] UNIV WISCONSIN,GENET LAB,MADISON,WI 53706

来源：

NATURE | 1990年 / 348卷 / 6303期

关键词：

D O I：

10.1038/348744a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4-6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides. © 1990 Nature Publishing Group.

引用

页码：744 / 747

页数：4

共 29 条

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