LONG-TERM TOXICITY/CARCINOGENICITY STUDY OF CALCIUM LACTATE IN F344 RATS

被引：12

作者：

MAEKAWA, A

MATSUSHIMA, Y

ONODERA, H

SHIBUTANI, M

YOSHIDA, J

KODAMA, Y

KUROKAWA, Y

HAYASHI, Y

机构：

[1] NATL INST HYG SCI,BIOL SAFETY RES CTR,DIV PATHOL,SETAGAYA KU,TOKYO 158,JAPAN

[2] NATL INST HYG SCI,BIOL SAFETY RES CTR,DIV TOXICOL,SETAGAYA KU,TOKYO 158,JAPAN

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1991年 / 29卷 / 09期

关键词：

D O I：

10.1016/0278-6915(91)90139-X

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats. Calcium lactate was given ad lib. in the drinking-water at levels of 0, 2.5 or 5% to groups of 50 male and 50 female rats for two years. No clear toxic lesion was specifically caused by long-term administration of calcium lactate. No significant dose-related increase was found in the incidences of tumours in any organ or tissue. The results indicated that calcium lactate had neither toxic nor carcinogenic activity in F344 rats.

引用

页码：589 / 594

页数：6

共 11 条

[1] INHIBITION OF INTESTINAL CARCINOGENESIS BY DIETARY SUPPLEMENTATION WITH CALCIUM [J].