CHANGES IN CEREBROSPINAL-FLUID AND PLASMA AMINO-ACID-CONCENTRATIONS WITH ELEVATED DIETARY-PROTEIN CONCENTRATION IN DOGS WITH PORTACAVAL SHUNTS

被引:11
作者
SCHAEFFER, MC
ROGERS, QR
LEUNG, PMB
WOLFE, BM
STROMBECK, DR
机构
[1] UNIV CALIF DAVIS,SCH VET MED,DEPT PHYSIOL SCI,DAVIS,CA 95616
[2] UNIV CALIF DAVIS,SCH VET MED,DEPT MED,DAVIS,CA 95616
[3] UNIV CALIF DAVIS,SCH MED,DEPT SURG,DAVIS,CA 95616
关键词
D O I
10.1016/0024-3205(91)90335-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Effects of dietary protein concentration on plasma and cerebrospinal fluid (CSF) amino acids (AA) in dogs with portacaval shunts (PCS) were examined. An 18% protein purified diet (18P) was fed to 4 PCS dogs and 2 controls; at week 10, 2 of the PCS dogs were switched to 36% protein (36P) until week 28. Effects of the diet switch on plasma and CSF AA in 8 normal dogs were determined in another experiment. Neither surgery nor protein level significantly affected average food intake (weeks 10-28). Plasma amino acid patterns typical of PCS animals were observed: phenylalanine and tyrosine increased and branched chain AA decreased with shunting (p < 0.05). Plasma phenylalanine increased further with 36P in PCS dogs (p < 0.05), but was not affected by dietary protein concentration in controls. With 36P: CSF arginine, serine, histidine, tryptophan, phenylalanine, glutamate and glutamine increased in PCS dogs; but only arginine decreased in CSF of controls (p < 0.05). In PCS dogs, significant CSF AA changes with elevated dietary protein were unrelated to plasma AA changes.
引用
收藏
页码:2215 / 2223
页数:9
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