DIASTEREOSELECTIVE ADDITION OF CHIRAL IMINES AND 1,3-OXAZOLIDINES WITH GRIGNARD-REAGENTS - ASYMMETRIC-SYNTHESIS OF (R)-2-ARYL- AND (R,R)-2,5-BIS(ARYL)PYRROLIDINES
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作者:
HIGASHIYAMA, K
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机构:Faculty of Pharmaceutical Science, Hoshi University, Shinagawa-ku, Tokyo, 142
HIGASHIYAMA, K
INOUE, H
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机构:Faculty of Pharmaceutical Science, Hoshi University, Shinagawa-ku, Tokyo, 142
INOUE, H
TAKAHASHI, H
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机构:Faculty of Pharmaceutical Science, Hoshi University, Shinagawa-ku, Tokyo, 142
TAKAHASHI, H
机构:
[1] Faculty of Pharmaceutical Science, Hoshi University, Shinagawa-ku, Tokyo, 142
Asymmetric syntheses of (R)-2-aryl- and (R,R)-2,5-bis(aryl)pyrrolidines were described starting from chiral aromatic imines derived from (R)-phenylglycinol, in which the diastereoselective additions of Grignard reagents to the chiral imines and 1,3-oxazolidines were used as the key reaction step.