DIASTEREOSELECTIVE ADDITION OF CHIRAL IMINES AND 1,3-OXAZOLIDINES WITH GRIGNARD-REAGENTS - ASYMMETRIC-SYNTHESIS OF (R)-2-ARYL- AND (R,R)-2,5-BIS(ARYL)PYRROLIDINES

被引:77
作者
HIGASHIYAMA, K
INOUE, H
TAKAHASHI, H
机构
[1] Faculty of Pharmaceutical Science, Hoshi University, Shinagawa-ku, Tokyo, 142
关键词
D O I
10.1016/S0040-4020(01)80819-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Asymmetric syntheses of (R)-2-aryl- and (R,R)-2,5-bis(aryl)pyrrolidines were described starting from chiral aromatic imines derived from (R)-phenylglycinol, in which the diastereoselective additions of Grignard reagents to the chiral imines and 1,3-oxazolidines were used as the key reaction step.
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页码:1083 / 1092
页数:10
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