SECRETED NOGGIN PROTEIN MIMICS THE SPEMANN ORGANIZER IN DORSALIZING XENOPUS MESODERM

被引：326

作者：

SMITH, WC ^{[1
]}

KNECHT, AK ^{[1
]}

WU, M ^{[1
]}

HARLAND, RM ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,DIV BIOCHEM & MOLEC BIOL,401 BARKER HALL,BERKELEY,CA 94720

来源：

NATURE | 1993年 / 361卷 / 6412期

关键词：

D O I：

10.1038/361547a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A DORSALIZING signal acts during gastrulation to change the specification of lateral mesodermal tissues from ventral (blood, mesenchyme) to more dorsal fates (muscle, heart, pronephros)1-3. This signal, from Spemann's organizer, cannot be mimicked by the mesoderm inducers activin and fibroblast growth factor2. The gene noggin is expressed in the organizer 4, and could be the dorsalizing signal. Here we show that soluble noggin protein added to ventral marginal zones during gastrulation induces muscle, but that activin does not. Dorsal pattern can be partially rescued in ventralized embryos by injection of a plasmid that expresses noggin during gastrulation. The results suggest that the noggin product may be the dorsalizing signal from the organizer.

引用

页码：547 / 549

页数：3

共 20 条

[1] EXPRESSION OF A DOMINANT NEGATIVE MUTANT OF THE FGF RECEPTOR DISRUPTS MESODERM FORMATION IN XENOPUS EMBRYOS
AMAYA, E
MUSCI, TJ
KIRSCHNER, MW
[J]. CELL, 1991, 66 (02) : 257 - 270
[2] BOLCE ME, 1992, DEVELOPMENT, V115, P681
[3] CHRISTIAN JL, IN PRESS GENES DEV
[4] CONDIE BG, 1987, DEVELOPMENT, V101, P93
[5] DALE L, 1987, DEVELOPMENT, V100, P279
[6] DWORKINRASTL E, 1986, J EMBRYOL EXP MORPH, V91, P153
[7] HARLAND R, 1988, DEVELOPMENT, V102, P837
[8] HEMMATIBRIVANLOU A, 1990, DEVELOPMENT, V110, P325
[9] A TRUNCATED ACTIVIN RECEPTOR INHIBITS MESODERM INDUCTION AND FORMATION OF AXIAL STRUCTURES IN XENOPUS EMBRYOS
HEMMATIBRIVANLOU, A
MELTON, DA
[J]. NATURE, 1992, 359 (6396) : 609 - 614
[10] THE ENTIRE MESODERMAL MANTLE BEHAVES AS SPEMANN ORGANIZER IN DORSOANTERIOR ENHANCED XENOPUS-LAEVIS EMBRYOS
KAO, KR
ELINSON, RP
[J]. DEVELOPMENTAL BIOLOGY, 1988, 127 (01) : 64 - 77

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