THE PUTATIVE ANTI-ADDICTIVE DRUG IBOGAINE IS A COMPETITIVE INHIBITOR OF [H-3] MK-801 BINDING TO THE NMDA RECEPTOR COMPLEX

被引：75

作者：

POPIK, P

LAYER, RT

SKOLNICK, P

机构：

[1] Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, 20892-0008, MD, Building 8

来源：

PSYCHOPHARMACOLOGY | 1994年 / 114卷 / 04期

关键词：

MK-801 (DIZOCILPINE); IBOGAINE; NMDA RECEPTORS; DRUG ABUSE;

D O I：

10.1007/BF02245000

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. We now report ibogaine is a competitive inhibitor (K-i, 1.01 +/- 0.1 mu M) of [H-3]MK-801 binding to N-methyl-D-aspartate (NMDA) receptor coupled cation channels. Since MK-801 can attenuate the development of tolerance to morphine and alcohol as well as sensitization to stimulants in preclinical studies, the reported ability of ibogaine to modify drug-seeking behavior in man may be attributable to a blockade of NMDA receptor coupled cation channels.

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收藏

页码：672 / 674

页数：3

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