CLONING OF A HUMAN COLLAGEN-BINDING PROTEIN, AND ITS HOMOLOGY WITH RAT GP46, CHICK HSP47 AND MOUSE J6 PROTEINS

被引：48

作者：

CLARKE, EP ^{[1
]}

SANWAL, BD ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO, DEPT BIOCHEM, LONDON N6H 2N9, ONTARIO, CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1129卷 / 02期

关键词：

COLLIGIN; CDNA SEQUENCE; HSP47; GP46; COLLAGEN-BINDING PROTEIN;

D O I：

10.1016/0167-4781(92)90498-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several cDNA clones encoding a collagen-binding protein were isolated from human fibroblasts. The cDNA encoded a 417 amino acid protein, containing two potential N-linked oligosaccharide binding sites and a C-terminal RDEL sequence, which has been shown to act as an endoplasmic retention signal in other systems. The derived amino acid sequence of the protein shows close homology with gp46 from rat skeletal myoblasts, J6 protein from mouse F9 embryonal carcinoma cells and hsp47 from chick embryo fibroblasts. It also shows sequence similarity with members of the serpin family.

引用

页码：246 / 248

页数：3

共 25 条

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