MATHEMATICAL BIOLOGY OF HIV INFECTIONS - ANTIGENIC VARIATION AND DIVERSITY THRESHOLD

被引：139

作者：

NOWAK, MA

MAY, RM

机构：

[1] Department of Zoology, University of Oxford, OX1 3PS Oxford, England

来源：

MATHEMATICAL BIOSCIENCES | 1991年 / 106卷 / 01期

关键词：

D O I：

10.1016/0025-5564(91)90037-J

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infection with the human immunodeficiency virus (HIV) results in severe damage to the immune system and consequent disease (AIDS) after a long and variable incubation period (on average 8-10 years). Why the incubation period should be so long is a puzzle. We outline an explanation based on the dynamics of the interplay between the immune response and antigenic variation in the virus population. The essential idea is that AIDS results when the diversity of antigenic variants of HIV in an infected patient exceeds some threshold, beyond which the immune system can no longer cope. The paper develops a simple mathematical model for this process, based on experimental observations, and explores several ramifications.

引用

页码：1 / 21

页数：21

共 21 条

[1]

ASCHER MS, 1990, J ACQ IMMUN DEF SYND, V3, P177

[2] CONCURRENT EVOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN PATIENTS INFECTED FROM THE SAME SOURCE - RATE OF SEQUENCE CHANGE AND LOW-FREQUENCY OF INACTIVATING MUTATIONS [J].