HIGH-DOSE CHEMOTHERAPY WITH STEM-CELL TRANSPLANTATION IN A METASTATIC MEDULLOBLASTOMA IN AN ADULT - A CASE-REPORT AND REVIEW OF THE LITERATURE

被引:7
作者
COTTU, PH
GIACCHETTI, S
MIGNOT, L
EPARDEAU, B
VISOT, B
EXTRA, JM
ESPIE, M
MARTY, M
机构
[1] HOP ST LOUIS, DEPT MED ONCOL, PARIS, FRANCE
[2] HOP FOCH, DEPT MED ONCOL, SURESNES, FRANCE
[3] HOP FOCH, DEPT HISTOL, SURESNES, FRANCE
[4] HOP FOCH, DEPT NEUROSURG, SURESNES, FRANCE
关键词
MESTASTATIC MEDULLOBLASTOMA; ADULT; HIGH-DOSE CHEMOTHERAPY; AUTOLOGOUS STEM-CELL TRANSPLANTATION;
D O I
10.1007/BF01324599
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Medulloblastoma is a rare tumor in adult. High doses of megavoltage irradiation of the posterior fossa have been resulted in a better survival (48 to 78% at 5 years) of the patient. It is sensitive to a wide variety of chemotherapy drugs, but adjuvant chemotherapy has not been proved effective in adults although data are limited. We report the case of a cerebellar medulloblastoma with bony and medullar metastases. High-dose chemotherapy with peripheral stem-cell transplantation was performed while the patient was in remission following conventional chemotherapy. Complete remission lasted for 8 months. This therapeutic approach of metastatic medulloblastoma might be of value as this tumor is chemosensitive and not cured by conventional treatment. Internal radiotherapy by Samarium-153 was also carried out and proved to be an effective palliative treatment of pain.
引用
收藏
页码:19 / 23
页数:5
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