AGE-RELATED DIGOXIN-ALPRAZOLAM INTERACTION

被引：10

作者：

GUVEN, H

TUNCOK, Y

GUNERI, S

CAVDAR, C

FOWLER, J

机构：

[1] DOKUZ EYLUL UNIV HOSP,DEPT INTERNAL MED,DIV CARDIOL,IZMIR 35340,TURKEY

[2] DOKUZ EYLUL UNIV HOSP,DEPT EMERGENCY MED,IZMIR 35340,TURKEY

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1993年 / 54卷 / 01期

关键词：

D O I：

10.1038/clpt.1993.107

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration-time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam.

引用

页码：42 / 44

页数：3