A CONVENIENT CHEMOENZYMATIC SYNTHESIS OF (R)-(CHLOROMETHYL)OXIRANE AND (S)-(CHLOROMETHYL)OXIRANE

被引:23
作者
CHEN, CS
LIU, YC
MARSELLA, M
机构
[1] Department of Pharmacognosy and Environmental Health Sciences, College of Pharmacy, University of Rhode Island, Kingston
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 09期
关键词
D O I
10.1039/p19900002559
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(R)- and (S)-1-Chloro-3-tosyloxypropan-2-ol have been prepared by biocatalysed enantioselective esterification in hexane, and in turn could be readily converted into optically active (chloromethyl)oxirane in high yield.
引用
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页码:2559 / 2561
页数:3
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