PHYSICAL MAPPING OF THE MEC REGION OF AN AMERICAN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS STRAIN

被引：36

作者：

DUBIN, DT ^{[1
]}

MATTHEWS, PR ^{[1
]}

CHIKRAMANE, SG ^{[1
]}

STEWART, PR ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,FAC SCI,DIV BIOCHEM & MOLEC BIOL,CANBERRA,ACT 2601,AUSTRALIA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 08期

关键词：

D O I：

10.1128/AAC.35.8.1661

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We mapped part of the mec region of a locally prevalent strain of Staphylococcus aureus. The mec region was found to harbor an insert of the transposon Tn554, which encodes spectinomycin and macrolide-lincosamide-streptogramin B resistance, and a 4.6-kb segment of DNA that contains the kanamycin resistance gene aadD. This 4.6-kb segment appears to be an integrated form of a previously described plasmid, pUB110, and is flanked by copies of the insertion sequence IS257. The integration event may be an example of processes that have led to accretion of resistance determinants in the mec region of S. aureus.

引用

页码：1661 / 1665

页数：5

共 31 条

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