RAPID TOLERANCE TO ACUTE PSYCHOMOTOR IMPAIRMENT WITH CARBAMAZEPINE IN EPILEPTIC PATIENTS

被引：11

作者：

LARKIN, JG ^{[1
]}

MCKEE, PJW ^{[1
]}

BRODIE, MJ ^{[1
]}

机构：

[1] UNIV GLASGOW,WESTERN INFIRM,DEPT MED & THERAPEUT,EPILEPSY RES UNIT,GLASGOW G11 6NT,SCOTLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 01期

关键词：

CARBAMAZEPINE; PSYCHOMOTOR TESTS; TOLERANCE; COGNITIVE FUNCTION; EPILEPSY;

D O I：

10.1111/j.1365-2125.1992.tb04009.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thirteen patients with newly diagnosed epilepsy performed a battery of psychomotor function tests before and during the first 12 weeks of carbamazepine (CBZ) therapy. Movement time (P < 0.025), total choice reaction time (P < 0.025), finger tapping rate (P < 0.005) and number cancellation (P < 0.05) were all significantly impaired after 1 week's treatment, but had returned to baseline by 4 weeks. Mean (+/- s.d.) serum CBZ concentrations and those of its active metabolite CBZ 10,11 epoxide (CBZ-E) were comparable at 1 (CBZ: 8.5 +/- 2.1 mg l-1, CBZ-E: 1.1 +/- 0.68 mg l-1) and 4 weeks (CBZ: 8.1 +/- 4.4 mg l-1, CBZ-E: 0.93 +/- 0.27 mg l-1). These results suggest the rapid development of tolerance to the acute deleterious psychomotor effects of CBZ.

引用

页码：111 / 114

页数：4

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