CDW50 AND ICAM-3 - 2 NAMES FOR THE SAME MOLECULE

被引：38

作者：

JUAN, M

VILELLA, R

MILA, J

YAGUE, J

MIRALLES, A

CAMPBELL, KS

FRIEDRICH, RJ

CAMBIER, J

VIVES, J

DEFOUGEROLLES, AR

SPRINGER, TA

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DENVER,CO

[2] HARVARD UNIV,SCH MED,COMM IMMUNOL,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[4] CTR BLOOD RES,BOSTON,MA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 07期

关键词：

CDW50; ICAM-3; LFA-1;

D O I：

10.1002/eji.1830230717

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CDw50 differentiation antigen is a molecule broadly expressed on hematopoetic cells but not on other cells. Previous experiments showed that CDw50 monoclonal antibodies (mAb) inhibited primary mixed lymphocyte culture (MLC). To understand the function of CDw50 better, we purified it and obtained peptide sequence. At the same time, intercellular adhesion molecule (ICAM)-3, the third ligand of lymphocyte function-associated molecule 1, was described by mAb and subsequent cDNA cloning. Immunochemical, functional, and protein sequencing studies show that ICAM-3 and CDw50 are the same glycoprotein, a 120-kDa surface molecule with presumably an important role in the immune responses.

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收藏

页码：1508 / 1512

页数：5

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