BIOCHEMICAL-CHANGES WITHIN A MULTIPLE-SCLEROSIS PLAQUE INVIVO

被引：24

作者：

CADOUXHUDSON, TAD ^{[1
]}

KERMODE, A ^{[1
]}

RAJAGOPALAN, B ^{[1
]}

TAYLOR, D ^{[1
]}

THOMPSON, AJ ^{[1
]}

ORMEROD, IEC ^{[1
]}

MCDONALD, WI ^{[1
]}

RADDA, GK ^{[1
]}

机构：

[1] NATL HOSP,MULTIPLE SCLEROSIS NUCL MAGNET RESONANCE RES GRP,LONDON WC1N 3BG,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 11期

关键词：

D O I：

10.1136/jnnp.54.11.1004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with an increase in the phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction in size of the lesion on MRI and normal intracellular biochemistry by MRS. Four MS patients without visible superficial cerebral lesions showed no significant changes in phosphorus metabolism.

引用

页码：1004 / 1006

页数：3

共 15 条

[1]

BARNES D, UNPUB

[2] MEASUREMENT OF LOCALIZED P-31 SPIN-LATTICE RELAXATION RATES INVIVO USING PMRFI-IR [J].

BLACKLEDGE, MJ ;

STYLES, P .

JOURNAL OF MAGNETIC RESONANCE, 1989, 83 (02) :390-399

[3] QUANTITATIVE STUDIES OF HUMAN CARDIAC METABOLISM BY P-31 ROTATING-FRAME NMR [J].

BLACKLEDGE, MJ ;

RAJAGOPALAN, B ;

OBERHAENSLI, RD ;

BOLAS, NM ;

STYLES, P ;

RADDA, GK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) :4283-4287

[4]

BRENTON DP, 1985, LANCET, V1, P115

[5] HUMAN PRIMARY BRAIN-TUMOR METABOLISM INVIVO - A PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY STUDY [J].

CADOUXHUDSON, TAD ;

BLACKLEDGE, MJ ;

RAJAGOPALAN, B ;

TAYLOR, DJ ;

RADDA, GK .

BRITISH JOURNAL OF CANCER, 1989, 60 (03) :430-436

[6] NMR-STUDIES OF METABOLITES IN LIVING TISSUE [J].

ILES, RA ;

STEVENS, AN ;

GRIFFITHS, JR .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1982, 15 :49-+

[7] MULTIPLE-SCLEROSIS - A SERIAL STUDY USING MRI IN RELAPSING PATIENTS [J].

ISAAC, C ;

LI, DKB ;

GENTON, M ;

JARDINE, C ;

GROCHOWSKI, E ;

PALMER, M ;

KASTRUKOFF, LF ;

OGER, J ;

PATY, DW .

NEUROLOGY, 1988, 38 (10) :1511-1515

[8] HETEROGENEITY OF BLOOD-BRAIN-BARRIER CHANGES IN MULTIPLE-SCLEROSIS - AN MRI STUDY WITH GADOLINIUM-DTPA ENHANCEMENT [J].

KERMODE, AG ;

TOFTS, PS ;

THOMPSON, AJ ;

MACMANUS, DG ;

RUDGE, P ;

KENDALL, BE ;

KINGSLEY, DPE ;

MOSELEY, IF ;

DUBOULAY, EPGH ;

MCDONALD, WI .

NEUROLOGY, 1990, 40 (02) :229-235

[9] CREATINE UPTAKE, METABOLISM, AND EFFLUX IN HUMAN-MONOCYTES AND MACROPHAGES [J].

LOIKE, JD ;

SOMES, M ;

SILVERSTEIN, SC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (01) :C128-C135

[10] LESSONS FROM MAGNETIC-RESONANCE IMAGING IN MULTIPLE-SCLEROSIS [J].

MCDONALD, WI ;

BARNES, D .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :376-379

← 1 2 →