EFFECTS OF A PHYSIOLOGICAL DOSE OF CHOLECYSTOKININ ON FOOD-INTAKE AND POSTPRANDIAL SATIATION IN MAN

被引:52
作者
LIEVERSE, RJ [1 ]
JANSEN, JBMJ [1 ]
VANDEZWAN, A [1 ]
SAMSON, L [1 ]
MASCLEE, AAM [1 ]
LAMERS, CBHW [1 ]
机构
[1] UNIV HOSP NIJMEGEN,DEPT GASTROENTEROL & HEPATOL,NIJMEGEN,NETHERLANDS
关键词
CHOLECYSTOKININ; PHYSIOLOGICAL DOSE; FOOD INTAKE; HUMAN;
D O I
10.1016/0167-0115(93)90410-A
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CCK-33 was infused intravenously to groups of 9 lean and 9 obese volunteers in doses that elicited plasma CCK concentrations in the physiological range. The effect of these infusions on food intake and satiety signals was compared with the effect of saline infusions in the same subjects. Food intake (486 +/- 52 g; mean +/- S.E.M.) was slightly, but not significantly decreased (553 +/- 55 g after saline), and hunger and fullness feelings after eating were unaffected, in both of the two groups. We conclude that the infusion of CCK-33 to plasma levels comparable to those observed after a fatty meal does not have a major effect on food intake and postprandial hunger feelings.
引用
收藏
页码:83 / 89
页数:7
相关论文
共 22 条
  • [1] CHOLECYSTOKININ SUPPRESSES FOOD-INTAKE IN CATS - STRUCTURE-ACTIVITY CHARACTERIZATION
    BADO, A
    RODRIGUEZ, M
    LEWIN, MJM
    MARTINEZ, J
    DUBRASQUET, M
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 31 (02) : 297 - 303
  • [2] CNS INJECTION OF CCK IN RATS - EFFECTS ON REAL AND SHAM FEEDING AND GASTRIC-EMPTYING
    DELLAFERA, MA
    COLEMAN, BD
    BAILE, CA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (05): : R1165 - R1169
  • [3] EFFECTS OF THE CCK RECEPTOR ANTAGONIST MK-329 ON FOOD-INTAKE IN PIGS
    EBENEZER, IS
    DELARIVA, C
    BALDWIN, BA
    [J]. PHYSIOLOGY & BEHAVIOR, 1990, 47 (01) : 145 - 148
  • [4] INTRAVENTRICULAR CCK INHIBITS FOOD-INTAKE AND GASTRIC-EMPTYING IN BABOONS
    FIGLEWICZ, DP
    SIPOLS, AJ
    PORTE, D
    WOODS, SC
    LIDDLE, RA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06): : R1313 - R1317
  • [5] TEMPORAL RELATIONSHIPS OF CHOLECYSTOKININ RELEASE, PANCREATOBILIARY SECRETION, AND GASTRIC-EMPTYING OF A MIXED MEAL
    FRIED, M
    MAYER, EA
    JANSEN, JBMJ
    LAMERS, CBHW
    TAYLOR, IL
    BLOOM, SR
    MEYER, JH
    [J]. GASTROENTEROLOGY, 1988, 95 (05) : 1344 - 1350
  • [6] CHOLECYSTOKININ DECREASES FOOD INTAKE IN RATS
    GIBBS, J
    YOUNG, RC
    SMITH, GP
    [J]. JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1973, 84 (03): : 488 - 495
  • [7] EFFECTS OF A NEW CHOLECYSTOKININ ANALOG (JMV-236) ON FOOD-INTAKE AND BRAIN MONOAMINES IN THE RAT
    GOURCH, A
    OROSCO, M
    RODRIGUEZ, M
    MARTINEZ, J
    COHEN, Y
    JACQUOT, C
    [J]. NEUROPEPTIDES, 1990, 15 (01) : 37 - 41
  • [8] DUODENAL INFUSION OF FAT, CHOLECYSTOKININ SECRETION AND SATIETY IN THE PIG
    GREGORY, PC
    MCFADYEN, M
    RAYNER, DV
    [J]. PHYSIOLOGY & BEHAVIOR, 1989, 45 (05) : 1021 - 1024
  • [9] THE CHOLECYSTOKININ RECEPTOR ANTAGONIST L364,718 INCREASES FOOD-INTAKE IN THE RAT BY ATTENUATION OF THE ACTION OF ENDOGENOUS CHOLECYSTOKININ
    HEWSON, G
    LEIGHTON, GE
    HILL, RG
    HUGHES, J
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (01) : 79 - 84
  • [10] MOLECULAR-FORMS OF CHOLECYSTOKININ IN PLASMA FROM NORMAL AND GASTRECTOMIZED HUMAN-SUBJECTS FOLLOWING A FAT MEAL
    JANSEN, JBMJ
    LAMERS, CBHW
    [J]. PEPTIDES, 1987, 8 (05) : 801 - 805