EPENDYMAL CELLS OF THE CHOROID-PLEXUS EXPRESS TUMOR-NECROSIS-FACTOR-ALPHA

被引：50

作者：

TARLOW, MJ

JENKINS, R

COMIS, SD

OSBORNE, MP

STEPHENS, S

STANLEY, P

CROCKER, J

机构：

[1] CELLTECH LTD,SLOUGH,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,DEPT HISTOPATHOL,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[3] UNIV BIRMINGHAM,DEPT PAEDIAT,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[4] UNIV BIRMINGHAM,DEPT PHYSIOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1993年 / 19卷 / 04期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; CHOROID PLEXUS; EPENDYMAL CELLS; BACTERIAL MENINGITIS; INFLAMMATION;

D O I：

10.1111/j.1365-2990.1993.tb00447.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tumour necrosis factor-alpha (TNFalpha) is a major pro-inflammatory cytokine which appears in the cerebrospinal fluid very early after endotoxin challenge, and is likely to be produced locally. Following in vivo and in vitro challenge with endotoxin, we have demonstrated immunocytochemically and by in situ hybridization that pig and guinea-pig choroid plexus ependymal cells can produce TNFalpha. Immuno-electron microscopy shows that this protein is localized within ependymal cells to the cytoplasm and microvilli. We suggest that this TNFalpha may be important in the initiation of the inflammatory response in bacterial meningitis.

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页码：324 / 328

页数：5

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