ENZYMATIC-SYNTHESIS OF BETA-N-ACETYLHEXOSAMINIDES OF ERGOT ALKALOIDS

被引：20

作者：

KREN, V

SCIGELOVA, M

PRIKRYLOVA, V

HAVLICEK, V

SEDMERA, P

机构：

[1] Institute of Microbiology, Academy of Sciences of the Czech Republic, CZ-142 20, Prague 4

来源：

BIOCATALYSIS | 1994年 / 10卷 / 1-4期

关键词：

BETA-N-ACETYLHEXOSAMINIDES; ERGOT ALKALOIDS; ASPERGILLUS ORYZAE; TRANSGLYCOSYLATION;

D O I：

10.3109/10242429409065228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Acetamido-2-deoxy-O-beta-D-galactopyranosides and 2-acetamido-2-deoxy-O-beta-D-glucopyranosides of the representatives of the three classes of the ergot alkaloids, i.e., elymoclavine (1a) (clavines), chanoclavine (2a) (secoclavines) and ergometrine (3a)/ergometrinine (4a) (lysergic/iso-lysergic acid derivatives) were prepared via transglycosylation catalysed by beta-N-acetylhexosaminidase from Aspergillus oryzae.

引用

页码：181 / 193

页数：13

共 14 条

[1]

Berde B, 1978, ERGOT ALKALOIDS RELA

[2]

CROUT DHG, 1991, J CHEM SOC CHEM COMM, P1550

[3] BIOTRANSFORMATIONS IN CARBOHYDRATE SYNTHESIS - N-ACETYLGALACTOSAMINYL TRANSFER ON TO METHYL N-ACETYL-BETA-DEUTERIUM-GLUCOSAMINIDE (METHYL 2-ACETAMIDO-2-DEOXY-BETA-DEUTERIUM-GLUCOPYRANOSIDE) AND METHYL N-ACETYL-ALPHA-DEUTERIUM-GLUCOSAMINIDE (METHYL 2-ACETAMIDO-2-DEOXY-ALPHA-DEUTERIUM-GLUCOPYRANOSIDE) CATALYZED BY A BETA-N-ACETYLGALACTOSAMINIDASE FROM ASPERGILLUS-ORYZAE [J].