MECHANISM OF INHIBITORY EFFECTS OF CHELATING DRUGS ON LIPID-PEROXIDATION IN RAT-BRAIN HOMOGENATES

被引：31

作者：

KOZLOV, AB

OSTRACHOVITCH, EA

AFANASEV, IB

机构：

[1] ALL UNION VITAMIN RES INST,117820 MOSCOW,RUSSIA

[2] STATE MED UNIV,MOSCOW 117513,RUSSIA

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 47卷 / 05期

关键词：

CHELATORS; LIPID PEROXIDATION; OXYGEN RADICALS;

D O I：

10.1016/0006-2952(94)90479-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of the inhibitory effects of chelators (desferrioxamine, EDTA, rutin, phenanthroline and ADP) on the production of oxygen radicals in the Fenton reaction and on lipid peroxidation of rat brain homogenates has been studied. It was found that the inhibitory effects of the chelators correlated well with their abilities to oxidize ferrous ions in solution and brain homogenates. On these grounds, it was concluded that the oxidation of Fe2+ ions inside a ferrous ion-chelator complex is a major mechanism of inhibitory effects of these chelators on free radical processes. It is proposed that this mechanism is also realized during therapeutic treatment with chelators of patients with ''free radical'' pathologies such as Fanconi anemia, beta-thalassemia and Diamond-Blackfan anemia.

引用

页码：795 / 799

页数：5

共 22 条

[1] IS SUPEROXIDE AN INITIATOR OF MICROSOMAL LIPID-PEROXIDATION [J].