CHEMOENZYMATIC SYNTHESIS OF (R)-4-AMINO-3-METHYLBUTANOIC AND (S)-4-AMINO-3-METHYLBUTANOIC ACIDS

被引：13

作者：

ANDRUSZKIEWICZ, R

BARRETT, AGM

SILVERMAN, RB

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

[2] NORTHWESTERN UNIV,DEPT MOLEC BIOL,EVANSTON,IL 60208

[3] NORTHWESTERN UNIV,DEPT BIOCHEM,EVANSTON,IL 60208

[4] NORTHWESTERN UNIV,DEPT CELL BIOL,EVANSTON,IL 60208

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 01期

关键词：

D O I：

10.1080/00397919008054627

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R) - and (S)-4-Amino-3-methylbutanoic acids were synthesized in high yields via initial enantioselective hydrolysis of dimethyl 3-methylglutarate to methyl (R)-3-methylglutarate with pig liver esterase. The ester group was converted to an amine to give (R)-4-araino-3-methylbutanoic acid; the carboxylic acid was converted to an amine to give (S)-4-amino-3-methylbutanoic acid. © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：159 / 166

页数：8

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