EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN COLORECTAL-CANCER

被引：79

作者：

STEELE, RJC

KELLY, P

ELLUL, B

EREMIN, O

机构：

[1] UNIV ABERDEEN,DEPT SURG,ABERDEEN AB9 1FX,SCOTLAND

[2] UNIV ABERDEEN,DEPT PATHOL,ABERDEEN AB9 1FX,SCOTLAND

来源：

BRITISH JOURNAL OF SURGERY | 1990年 / 77卷 / 12期

关键词：

COLORECTAL CARCINOMA; EPIDERMAL GROWTH FACTOR RECEPTOR;

D O I：

10.1002/bjs.1800771211

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Epidermal growth factor (EGF) receptor expression was estimated in 50 invasive human colorectal cancers using immunohistochemistry and the degree of expression was quantified from integrated optical density measurements on the stained sections. All tumours stained positively, but Dukes' C tumours exhibited significantly higher levels of receptor than either Dukes' A or B tumours. In addition, histologically high grade cancers expressed receptors more strongly than those of low grade. It is concluded that a high EGF receptor concentration is associated with poor prognostic factors in colorectal malignancy.

引用

页码：1352 / 1354

页数：3

共 23 条

[1] INCREASED EXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR ON HUMAN-COLON CARCINOMA-CELLS [J].

BRADLEY, SJ ;

GARFINKLE, G ;

WALKER, E ;

SALEM, R ;

CHEN, LB ;

STEELE, G .

ARCHIVES OF SURGERY, 1986, 121 (11) :1242-1247

[2] EPIDERMAL GROWTH-FACTOR [J].

CARPENTER, G ;

COHEN, S .

ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 :193-216

[3]

COHEN S, 1983, CANCER-AM CANCER SOC, V51, P1787, DOI 10.1002/1097-0142(19830515)51:10<1787::AID-CNCR2820511004>3.0.CO

[4]

2-A

[5]

DAMJANOV I, 1986, LAB INVEST, V55, P588

[6] CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].

DOWNWARD, J ;

YARDEN, Y ;

MAYES, E ;

SCRACE, G ;

TOTTY, N ;

STOCKWELL, P ;

ULLRICH, A ;

SCHLESSINGER, J ;

WATERFIELD, MD .

NATURE, 1984, 307 (5951) :521-527

[7] A RADIOIMMUNOASSAY FOR HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR [J].

GULLICK, WJ ;

DOWNWARD, DJH ;

MARSDEN, JJ ;

WATERFIELD, MD .

ANALYTICAL BIOCHEMISTRY, 1984, 141 (01) :253-261

[8] CELLULAR-LOCALIZATION OF HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR [J].

GUSTERSON, B ;

COWLEY, G ;

SMITH, JA ;

OZANNE, B .

CELL BIOLOGY INTERNATIONAL REPORTS, 1984, 8 (08) :649-658

[9] COLORECTAL-CARCINOMA - HISTOPATHOLOGICAL DIAGNOSIS AND STAGING [J].

HERMANEK, P .

BAILLIERES CLINICAL GASTROENTEROLOGY, 1989, 3 (03) :511-529

[10]

MARQUARDT H, 1983, P NATL ACAD SCI-BIOL, V80, P4684

← 1 2 3 →