PREPARATION OF THE ENANTIOMERS OF THE NOVEL CA-SENSITIZER EMD 53-998

被引：16

作者：

JONAS, R

KLOCKOW, M

LUES, I

机构：

[1] Pharmaceutical Research Department, E. Merck, Darmstadt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81203-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Both enantiomers of EMD 53 998 (1), a novel cardiotonic with Ca-sensitizing activity, were readily prepared by kinetic resolution of the N-acylthiadiazinone 2. The Ca-sensitizing effect is highly stereospecific and resides in the (+)-enantiomer. The (-)-entantiomer is a pure PDE inhibitor devoid of any Ca-sensitizing activity.

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页码：589 / 592

页数：4

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