DECREASED EXPRESSION OF NEUROTROPHIN-3 MESSENGER-RNA IN THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA

被引：36

作者：

TAKEDA, A

ONODERA, H

YAMASAKI, Y

FURUKAWA, K

KOGURE, K

OBINATA, M

SHIBAHARA, S

机构：

[1] TOHOKU UNIV,SCH MED,INST BRAIN DIS,DEPT NEUROL,AOBA KU,SENDAI,MIYAGI 980,JAPAN

[2] TOHOKU UNIV,TB & CANC RES INST,DEPT CELL BIOL,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 569卷 / 01期

关键词：

NEUROTROPHIC FACTOR; CEREBRAL ISCHEMIA; C-FOS; C-JUN; NEURONAL DEATH; GENE EXPRESSION;

D O I：

10.1016/0006-8993(92)90388-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression profile of neurotrophin-3 (NT-3) mRNA in the rat hippocampus after forebrain ischemia was investigated by Northern blot and S1 nuclease protection analyses. The NT-3 transcripts in the hippocampus immediately decreased after ischemic insult, became undetectable within 3 h and remained at undetectable levels for at least 7 days. In contrast, the expression of c-fos and c-jun mRNA transiently increased both in the cerebral cortex and in the hippocampus. These results suggest that brain ischemia triggers dynamic changes in gene expression including a neurotrophic factor, which may cause functional and/or morphological changes of the neuronal network.

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页码：177 / 180

页数：4

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