COMPARISON BETWEEN GD-DTPA, GD-EOB-DTPA, AND MN-DPDP IN INDUCED HCC IN RATS - A CORRELATION STUDY OF MR-IMAGING, MICROANGIOGRAPHY, AND HISTOLOGY

被引：49

作者：

MARCHAL, G

ZHANG, X

NI, Y

VANHECKE, P

YU, J

BAERT, AL

机构：

[1] Department of Radiology, University Hospitals K.U. Leuven, Leuven

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 05期

关键词：

MRI; HCC; GD-DTPA; GD-EOB-DTPA; MN-DPDP; CONTRAST ENHANCEMENT;

D O I：

10.1016/0730-725X(93)90008-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The behaviour of two liver-specific contrast MR agents, Gd-EOB-DTPA and Mn-DPDP and one nonspecific contrast agent, Gd-DTPA, was compared in a rat model of chemically induced hepatocellular carcinoma (HCC). The study included contrast enhanced MR imaging and the corresponding microangiography and histology. Analysis of the MR images showed similar degrees of maximum relative liver enhancement: 47.5 +/- 8.2% for Gd-EOB-DTPA (0.03 mmol/kg) at 5 min postinjection and 52.5 +/- 14.4% for Mn-DPDP (0.025 mmol/kg) at 15 min; both exceeded the value obtained with Gd-DTPA (34.8 +/- 13.6%, at 5 min), even at 0.3 mmol/kg. Gd-EOB-DTPA caused a similar ''negative'' enhancement of all types of HCC, independent of their differentiation and vascularization, i.e., lesion-to-liver contrast-to-noise ratio (CNR) of differentiated and undifferentiated HCC increased negatively from, respectively, 1.9 +/- 1.1 and -5.1 +/- 3.1 before contrast to -5.2 +/- 2.4 and -11.8 +/- 4.8 at 5 min after contrast. On Mn-DPDP enhanced images, the undifferentiated HCCs showed up negatively (CNR -5.5 +/- 4.7 before contrast to -13.7 +/- 10 at 15 min after contrast), whereas the more differentiated tumors showed up positively (CNR from 2.3 +/- 2.0 before contrast to 12.5 +/- 3.5 at 24 hr postcontrast) due to active uptake and delayed elimination of Mn-DPDP.

引用

页码：665 / 674

页数：10

共 13 条

[1]

Kuni, Yuji, Kohki, Et al., Hepatic tumors: Dynamic MR imaging, Radiology, 163, pp. 27-31, (1987)

[2]

Elizondo, Fretz, Stark, Rocklage, Quay, Worah, Tsang, Chen, Ferruci, Preclinical evaluation of MnDPDP: New paramagnetic hepatobiliary contrast agent for MR imaging, Radiology, 178, pp. 73-78, (1991)

[3]

Young, Simpson, Ratner, Carker, Matkin, MRI detection of hepatocyte function using a new MR contrast agent S-095 (a Manganese/Pyridoxal-5-Phosphate chelate), Presented at the 36th Annual Meeting of the Association of University Radiologists, (1988)

[4]

Young, Simpson, Ratner, Matkin, Carker, MRI measurement of hepatocyte toxicity using a new MRI contrast agent Mn-DPDP (manganese dipyridoxal diphosphate, a manganese/Pyridoxal-5-Phosphate chelate), Magn. Reson. Med., 10, pp. 1-13, (1989)

[5]

Young, Bradley, Muller, Rubin, Detection of hepatic malignancies using Mn-DPDP, Magn. Reson. Imaging, 8, pp. 267-276, (1990)

[6]

Rummeny, Ehrenheim, Gehl, Hamm, Laniado, Lodemann, Schmiedel, Steudel, Vogl, Manganese-DPDP as a hepatobiliary contrast agent in the magnetic resonance imaging of liver tumors. Results of clinic phase II trials in Germany including 141 patients, Invest. Radiol., 26, pp. S142-S145, (1991)

[7]

Hamm, Vogl, Branding, Schnell, Taupitz, Wolf, Lissner, Focal liver lesions: MR imaging with Mn-DPDP-initial clinical results in 40 patients, Radiology, 182, pp. 167-174, (1992)

[8]

Schuhmann-Giampieri, Schmitt-Willich, Press Chikashi Negishi, Weinmann, Speck, Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system, Radiology, 183, pp. 59-64, (1992)

[9]

Weinmann, Schuhmann-Giampieri, Schmitt-Willich, Vogler, Frenzen, Gries, A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI, Magn. Reson. Med., 22, pp. 233-237, (1991)

[10]

Clement, Muhler, Vexler, Berthezene, Brasch, Gadolinium-ethoxybenzyl-DTPA, a new liver-specific magnetic resonance contrast agent: Kinetic and enhancement patterns in normal and cholestatic rats, Invest. Radiol., 27, pp. 612-619, (1992)

← 1 2 →