SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF NEW SEMISYNTHETIC NOVIOSYLCOUMARIN ANTIBIOTICS - CHEMICAL MODIFICATION AT THE C-3' ESTER

被引：12

作者：

UEDA, Y

CHUANG, JM

FUNGTOMC, J

PARTYKA, RA

机构：

[1] Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, CT 06492-7660

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)80578-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthetic procedure to introduce a variety of ester groups at the C-3' position of the noviosylcoumarin antibiotics has been developed. Several new semi-synthetic noviosylcoumarins having unique ester groups at the C-3' position by this method were prepared and in vitro antibacterial (anti-staphylococcal) activity was evaluated.

引用

页码：1623 / 1628

页数：6

共 18 条

[1]

BERGER J, 1979, ANTIBIOTICS ISOLATIO, P101

[2]

BERGER J, J CHROMATOGRAPHY LIB, V15

[3]

BOLHOFER WA, 1980, Patent No. 4220654

[4] CHEMISTRY AND STRUCTURE OF GANEFROMYCIN [J].