PROGNOSTIC VALUE OF EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN CERVICAL-CARCINOMA

被引:79
作者
HALE, RJ
BUCKLEY, CH
GULLICK, WJ
FOX, H
WILLIAMS, J
WILCOX, FL
机构
[1] ROYAL VICTORIA HOSP,DEPT OBSTET & GYNAECOL,BLACKPOOL,ENGLAND
[2] HAMMERSMITH HOSP,ICRF,ONCOL GRP,LONDON W12 0HS,ENGLAND
关键词
D O I
10.1136/jcp.46.2.149
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aims: To investigate the pattern of epidermal growth factor receptor expression and its prognostic value in the three main types of cervical carcinoma. Methods: 62 cases of stage IB/IIA cervical carcinoma, all with a minimum of five years of follow up, were studied. Representative sections were stained for mucin to permit accurate tumour typing and a standard avidin-biotin immunoperoxidase technique using the polyclonal antibody 12E was used to demonstrate the presence of epidermal growth factor receptor. Results: A proportion of all three tumour types expressed epidermal growth factor receptor, it being most common in squamous cell carcinomas (50%). Overall, there was a correlation between epidermal growth factor expression and mortality. This was particularly obvious in the absence of lymph node metastases. When the individual tumour types were considered this association with prognosis was not demonstrable for squamous cell carcinomas or adenocarcinomas but was a very prominent feature of adenosquamous carcinomas. Conclusions: Immunohistochemical demonstration of epidermal growth factor receptor expression may be useful in identifying those patients with a poor prognosis, particularly those with adenosquamous carcinomas which have not metastasised to the regional lymph nodes.
引用
收藏
页码:149 / 153
页数:5
相关论文
共 36 条
  • [1] EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN GYNECOLOGICAL MALIGNANCIES
    BATTAGLIA, F
    SCAMBIA, G
    PANICI, PB
    BAIOCCHI, G
    PERRONE, L
    IACOBELLI, S
    MANCUSO, S
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1989, 27 (01) : 42 - 44
  • [2] THE OCCURRENCE OF EPIDERMAL GROWTH-FACTOR RECEPTORS AND THE CHARACTERIZATION OF EGF-LIKE FACTORS IN HUMAN OVARIAN, ENDOMETRIAL, CERVICAL AND BREAST-CANCER - EGF RECEPTORS AND FACTORS IN GYNECOLOGICAL CARCINOMAS
    BAUKNECHT, T
    KOHLER, M
    JANZ, I
    PFLEIDERER, A
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1989, 115 (02) : 193 - 199
  • [3] BERCHUCK A, 1990, OBSTET GYNECOL, V76, P381
  • [4] BUCKLEY CH, 1989, RECENT ADV HISTOPATH, V14, P63
  • [5] EPIDERMAL GROWTH-FACTOR
    CARPENTER, G
    COHEN, S
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 : 193 - 216
  • [6] EPIDERMAL GROWTH-FACTOR, ITS RECEPTOR, AND RELATED PROTEINS
    CARPENTER, G
    ZENDEGUI, JG
    [J]. EXPERIMENTAL CELL RESEARCH, 1986, 164 (01) : 1 - 10
  • [7] COHEN S, 1962, J BIOL CHEM, V237, P1555
  • [8] COHEN S, 1983, CANCER-AM CANCER SOC, V51, P1787, DOI 10.1002/1097-0142(19830515)51:10<1787::AID-CNCR2820511004>3.0.CO
  • [9] 2-A
  • [10] SIMILAR EFFECTS OF PLATELET-DERIVED GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR ON THE PHOSPHORYLATION OF TYROSINE IN CELLULAR PROTEINS
    COOPER, JA
    BOWENPOPE, DF
    RAINES, E
    ROSS, R
    HUNTER, T
    [J]. CELL, 1982, 31 (01) : 263 - 273