IMPACT OF MICROFILAREMIA ON MAINTENANCE OF A HYPORESPONSIVE CELLULAR IMMUNE-RESPONSE IN BRUGIA-INFECTED GERBILS (MERIONES-UNGUICULATUS)

被引:24
作者
BOSSHARDT, SC
COLEMAN, SU
MCVAY, CS
JONES, KL
KLEI, TR
机构
[1] LOUISIANA STATE UNIV,SCH VET MED,DEPT VET MICROBIOL & PARASITOL,BATON ROUGE,LA 70803
[2] CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341
关键词
D O I
10.1128/IAI.63.3.940-945.1995
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The purpose of these experiments was to define the significance of the microfilarial stage to the hyporesponsive condition seen in lymphatic filariasis. Two types of experiments were conducted with Brugia pahangi-infected gerbils. In one, in vitro lymphocyte blastogenesis and in vivo granuloma formation in response to parasite antigen were correlated to microfilaremia in chronically infected individuals. In a second set of experiments, the level of in vivo granuloma formation was assessed following chemotherapeutic removal of microfilariae with ivermectin. The results indicated that the microfilarial stage alone is not responsible for the maintenance of the low cellular responses seen during chronic infections in this model. Furthermore, the data suggest that the degree of downregulation of these responses may be related to parasite burden.
引用
收藏
页码:940 / 945
页数:6
相关论文
共 33 条
[1]   BRUGIA-PAHANGI - EFFECTS OF MATERNAL FILARIASIS ON THE RESPONSES OF THEIR PROGENY TO HOMOLOGOUS CHALLENGE INFECTION [J].
BOSSHARDT, SC ;
MCVAY, CS ;
COLEMAN, SU ;
KLEI, TR .
EXPERIMENTAL PARASITOLOGY, 1992, 74 (03) :271-282
[2]   REPEATED INFECTION OF CATS WITH BRUGIA-PAHANGI - PARASITOLOGICAL OBSERVATIONS [J].
DENHAM, DA ;
MEDEIROS, F ;
BALDWIN, C ;
KUMAR, H ;
MIDWINTER, ICT ;
BIRCH, DW ;
SMAIL, A .
PARASITOLOGY, 1992, 104 :415-420
[3]   EOSINOPHIL HYPORESPONSE OF JIRDS INDUCED BY MICROFILARIAE OF BRUGIA-PAHANGI [J].
HORII, Y ;
NAKANISHI, H ;
MORI, A ;
ZAITSU, M ;
UEDA, M ;
KUROKAWA, K ;
ODA, T ;
FUJITA, K .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1989, 41 (02) :183-188
[4]   CYTOKINE CONTROL OF PARASITE-SPECIFIC ANERGY IN HUMAN LYMPHATIC FILARIASIS - PREFERENTIAL INDUCTION OF A REGULATORY T-HELPER TYPE-2 LYMPHOCYTE SUBSET [J].
KING, CL ;
MAHANTY, S ;
KUMARASWAMI, V ;
ABRAMS, JS ;
REGUNATHAN, J ;
JAYARAMAN, K ;
OTTESEN, EA ;
NUTMAN, TB .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1667-1673
[5]   BRUGIA-PAHANGI - EFFECTS OF DURATION OF INFECTION AND PARASITE BURDEN ON LYMPHATIC LESION SEVERITY, GRANULOMATOUS HYPERSENSITIVITY, AND IMMUNE-RESPONSES IN JIRDS (MERIONES-UNGUICULATUS) [J].
KLEI, TR ;
MCVAY, CS ;
DENNIS, VA ;
COLEMAN, SU ;
ENRIGHT, FM ;
CASEY, HW .
EXPERIMENTAL PARASITOLOGY, 1990, 71 (04) :393-405
[6]   PHOSPHOCHOLINE-CONTAINING ANTIGENS OF BRUGIA-MALAYI NONSPECIFICALLY SUPPRESS LYMPHOCYTE FUNCTION [J].
LAL, RB ;
KUMARASWAMI, V ;
STEEL, C ;
NUTMAN, TB .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1990, 42 (01) :56-64
[7]   BANCROFTIAN FILARIASIS IN HAITI - PRELIMINARY CHARACTERIZATION OF THE IMMUNOLOGICAL RESPONSIVENESS OF MICROFILAREMIC INDIVIDUALS [J].
LAMMIE, PJ ;
LEIVA, LE ;
RUFF, AJ ;
EBERHARD, ML ;
LOWRIE, RC ;
KATZ, SP .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 38 (01) :125-129
[8]   THE EFFECT OF DIETHYLCARBAMAZINE TREATMENT OF BANCROFTIAN FILARIASIS ON THE IMMUNOLOGICAL REACTIVITY OF MICROFILAREMIC INDIVIDUALS [J].
LAMMIE, PJ ;
EBERHARD, ML ;
LEIVA, LE ;
LOWRIE, RC ;
KATZ, SP .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1988, 82 (05) :726-729
[9]  
LAMMIE PJ, 1983, J IMMUNOL, V130, P1386
[10]   ALTERATIONS IN FILARIAL ANTIGEN-SPECIFIC IMMUNOLOGICAL REACTIVITY FOLLOWING TREATMENT WITH IVERMECTIN AND DIETHYLCARBAMAZINE [J].
LAMMIE, PJ ;
HIGHTOWER, AW ;
RICHARDS, FO ;
BRYAN, RT ;
SPENCER, HC ;
MCNEELEY, DF ;
MCNEELEY, MB ;
EBERHARD, ML .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 46 (03) :292-295