KIDNEY AND LIVER CONTRIBUTIONS TO SALICYLATE METABOLISM IN RATS

被引：8

作者：

LAZNICEK, M

LAZNICKOVA, A

机构：

[1] Faculty of Pharmacy, Charles University, Hradec Králové, CS-501 65

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1994年 / 19卷 / 01期

关键词：

SALICYLATE; PHARMACOKINETICS; METABOLISM; PERFUSED RAT LIVER; PERFUSED RAT KIDNEY;

D O I：

10.1007/BF03188818

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives.

引用

页码：21 / 26

页数：6

共 12 条

[1]

BEKERSKY I, 1980, DRUG METAB DISPOS, V8, P319

[2] PROTEIN-BINDING OF TOLFENAMIC ACID IN THE PLASMA FROM PATIENTS WITH RENAL AND HEPATIC-DISEASE [J].