NEUROPATHOLOGY AND STRUCTURAL BRAIN IMAGING IN SCHIZOPHRENIA

In addition to replicated findings of cerebrospinal fluid space enlargement and limbic system pathology in schizophrenia, evidence is increasing of a subtle volume reduction in more widespread frontal and perisylvian cortical association areas. Moreover, in chronic patients, an increase in basal ganglia volumes, possibly caused by long-term neuroleptic treatment, has consistently been round. Pathomorphology has gained some prognostic significance for the course of schizophrenia, although the clinical usefulness of recently reported biological, neuropsychological, and psychopathological correlates of the anatomical findings remains to be established.