COST AND EFFICIENCY IN CLINICAL-TRIALS - THE UNITED-STATES PHYSICIANS HEALTH STUDY

被引：31

作者：

BURING, JE ^{[1
]}

HENNEKENS, CH ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,CHANNING LAB,BOSTON,MA 02115

来源：

STATISTICS IN MEDICINE | 1990年 / 9卷 / 1-2期

关键词：

D O I：

10.1002/sim.4780090109

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The U.S. Physicians' Health Study, a primary prevention trial of low‐dose aspirin in the reduction of cardiovascular disease and of beta‐carotene in lowering cancer risk, implemented a number of design strategies to decrease costs and increase efficiency. These included the choice of physicians as the study population, use of a factorial design, implementation of a pre‐randomization run‐in phase, and the collection of pre‐randomization blood specimens. The use of these strategies enabled us to enroll 22,071 subjects and maintain high compliance and long‐term follow‐up at a fraction of the usual cost of large‐scale trials of primary prevention. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：29 / 33

页数：5

共 11 条

[1]

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