QT PROLONGATION ON THE ELECTROCARDIOGRAM IN DIABETIC AUTONOMIC NEUROPATHY

被引：54

作者：

CHAMBERS, JB

SAMPSON, MJ

SPRIGINGS, DC

JACKSON, G

机构：

[1] Cardiac Departments, King's College Hospital, London

[2] Diabetic Departments, King's College Hospital, London

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 02期

关键词：

Autonomic neuropathy; QT interval; Type; 1; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01342.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with Type 1 diabetes and autonomic neuropathy have an increased risk of sudden death for which the mechanism remains obscure. Prolongation of the QT interval on the electrocardiogram may occur with sympathetic dysfunction and is also associated with ventricular arrhythmia and sudden death. We have therefore measured the QT interval in patients with Type 1 diabetes with normal, borderline, and definitely abnormal autonomic function tests and in non‐diabetic control subjects. The maximum QT interval was measured on 12‐lead electrocardiograms recorded at rest and then plotted against the RR interval. The QT interval was above the upper 95% limit for the non‐diabetic control subjects in 5 diabetic patients with abnormal autonomic function tests (33%), but in no cases with normal or borderline tests. Multivariate analysis confirmed that autonomic score contributed significantly (p < 0.025) to the variance in QT interval. The raw Valsalva ratio alone also contributed significantly to the variance in QT interval (p = 0.025). Heart rate variability, heart rate response to standing, age, sex, and the presence of symptoms of autonomic neuropathy did not contribute significantly. 1990 Diabetes UK

引用

页码：105 / 110

页数：6

共 28 条

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