SENSITIVITY OF BACTERIA TO NANO2 AND TO L-ARGININE-DEPENDENT SYSTEM IN MURINE MACROPHAGES

被引:31
作者
SAITO, S
ONOZUKA, K
SHINOMIYA, H
NAKANO, M
机构
[1] Department of Microbiology, Jichi Medical School
关键词
D O I
10.1111/j.1348-0421.1991.tb01561.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sensitivity of bacteria to NO2-/NO and to L-arginine-dependent system in murine macrophages was tested. The growth of all bacteria tested, Salmonella typhimurium, Pseudomonas aeruginosa and Staphylococcus epidermidis, was significantly inhibited by NaNO2 at the concentration of 5 to 10 mM. However, L-arginine-dependent effector mechanism of LPS-activated murine macrophages was ineffective in killing these bacteria. It seems that the concentration of NO2-/NO in phagolysosome in the activated macrophages in insufficient to kill the bacteria in situ. We concluded that L-arginine-dependent effector mechanism can hardly work on bacteria killing in activated macrophages.
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页码:325 / 329
页数:5
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