SUBSTRATE-SPECIFICITY AND INHIBITORS OF ASPARTIC PROTEINASES

被引：41

作者：

KAY, J ^{[1
]}

DUNN, BM ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,DEPT BIOCHEM & MOLEC BIOL,GAINESVILLE,FL 32610

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1992年 / 52卷

关键词：

ASPARTIC PROTEINASES; NATURALLY-OCCURRING AND RECOMBINANT; PEPSIN; RENIN; CHYMOSIN; CATHEPSIN-D; CATHEPSIN-E; HIV PROTEINASE; ACTIVE SITE MAPPING; INDIVIDUAL SUB-SITES; CHROMOGENIC SUBSTRATES; SPECIFIC INHIBITORS;

D O I：

10.3109/00365519209104651

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aspartic proteinases of vertebrate, fungal and retroviral origin have been characterised by utilisation of chromogenic peptide substrates and synthetic inhibitors as probes. By this means, the molecular topography of sub-sites within the active site cleft of individual enzymes has been elucidated. With suitable selection of residues to occupy each sub-site, the design of effective inhibitors specifically targetted against individual aspartic proteinases has become feasible.

引用

页码：23 / 30

页数：8

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