CYTOKINES IN SPUTUM AND SERUM FROM PATIENTS WITH CYSTIC-FIBROSIS AND CHRONIC PSEUDOMONAS-AERUGINOSA INFECTION AS MARKERS OF DESTRUCTIVE INFLAMMATION IN THE LUNGS

被引：92

作者：

KRONBORG, G ^{[1
]}

HANSEN, MB ^{[1
]}

SVENSON, M ^{[1
]}

FOMSGAARD, A ^{[1
]}

HOIBY, N ^{[1
]}

BENDTZEN, K ^{[1
]}

机构：

[1] RIGSHOSP, DANISH CF CTR, DK-2100 COPENHAGEN, DENMARK

来源：

PEDIATRIC PULMONOLOGY | 1993年 / 15卷 / 05期

关键词：

INTERLEUKINS; IL-RECEPTOR ANTAGONIST; TUMOR NECROSIS FACTOR; PULMONARY FUNCTION;

D O I：

10.1002/ppul.1950150506

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The presence of interleukin (IL)-1 receptor antagonist (IRAP) in plasma and sputum from patients with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infection was investigated together with IL-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha (TNF) in a cross-sectional study. All cytokines were assayed by ELISAs. High concentrations of IRAP, IL-1alpha, IL-1beta, IL-6, and TNF in sputum samples and low or nondetectable levels of circulating cytokines were frequently found. increased concentrations of plasma IRAP are positively correlated with decreasing pulmonary function. In a longitudinal study of serum IRAP, a higher level of IRAP was detected in a group of patients with poor pulmonary function compared to a group with good pulmonary function.

引用

页码：292 / 297

页数：6

共 23 条

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