IRON CHELATION AS A CHEMOTHERAPEUTIC STRATEGY FOR FALCIPARUM-MALARIA

被引:44
作者
GORDEUK, VR
THUMA, PE
BRITTENHAM, GM
BIEMBA, G
ZULU, S
SIMWANZA, G
KALENSE, P
MHANGO, A
PARRY, D
POLTERA, AA
AIKAWA, M
机构
[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,HERSHEY,PA 17033
[2] CIBA GEIGY AG,CH-4002 BASEL,SWITZERLAND
[3] MACHA MISSION HOSP,CHOMA,ZAMBIA
[4] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106
关键词
D O I
10.4269/ajtmh.1993.48.193
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To examine the effect of iron chelation against human malaria, 37 Zambians with asymptomatic Plasmodium falciparum infections were randomly assigned to 72-hr infusions of desferrioxamine B or placebo. Mean concentrations of ring forms decreased significantly with desferrioxamine B (P < 0.001) but not with a placebo. Over seven days of observation, mean parasite concentrations remained at the initial levels in six individuals originally given placebo, but decreased promptly with administration of desferrioxamine B (P = 0.001). Mean parasitemia was significantly lower for up to four weeks in 16 subjects treated with desferrioxamine B when compared with the eight who had received placebo only (P = 0.027). We conclude that iron chelation has antiplasmodial activity and may offer a new therapeutic strategy for falciparum malaria.
引用
收藏
页码:193 / 197
页数:5
相关论文
共 13 条
[1]   STAGE-SPECIFIC ULTRASTRUCTURAL EFFECTS OF DESFERRIOXAMINE ON PLASMODIUM-FALCIPARUM INVITRO [J].
ATKINSON, CT ;
BAYNE, MT ;
GORDEUK, VR ;
BRITTENHAM, GM ;
AIKAWA, M .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 45 (05) :593-601
[2]   MEASUREMENT OF IRON STORES USING DEFEROXAMINE [J].
BALCERZAK, SP ;
WESTERMAN, MP ;
HEINLE, EW ;
TAYLOR, FH .
ANNALS OF INTERNAL MEDICINE, 1968, 68 (03) :518-+
[3]  
GORDEUK VR, 1992, BLOOD, V79, P308
[4]   THE EFFECT OF IRON THERAPY ON MALARIAL INFECTION IN PAPUA NEW-GUINEAN SCHOOLCHILDREN [J].
HARVEY, PWJ ;
HEYWOOD, PF ;
NESHEIM, MC ;
GALME, K ;
ZEGANS, M ;
HABICHT, JP ;
STEPHENSON, LS ;
RADIMER, KL ;
BRABIN, B ;
FORSYTH, K ;
ALPERS, MP .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1989, 40 (01) :12-18
[5]  
HEPPNER DG, 1988, BLOOD, V72, P358
[6]   DEFEROXAMINE INHIBITION OF MALARIA IS INDEPENDENT OF HOST IRON STATUS [J].
HERSHKO, C ;
PETO, TEA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (01) :375-387
[7]  
PETERS W, 1990, PROG MED, V81, P749
[8]  
POLLACK S, 1987, P SOC EXP BIOL MED, V184, P162, DOI 10.3181/00379727-184-42461
[9]   CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF DEFEROXAMINE IN PATIENTS WITH IRON OVERLOAD [J].
PROPPER, RD ;
COOPER, B ;
RUFO, RR ;
NIENHUIS, AW ;
ANDERSON, WF ;
BUNN, HF ;
ROSENTHAL, A ;
NATHAN, DG .
NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (08) :418-423
[10]  
Shute G. T., 1988, Malaria: principles and practice of malariology. Volume 1., P781