OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT

被引：13

作者：

FRANCIS, TB

SMALLRIDGE, RC

KANE, J

MAGNER, JA

机构：

[1] WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC 20307 USA

[2] WALTER REED ARMY MED CTR, ENDOCRINE METAB SERV, WASHINGTON, DC 20307 USA

[3] UNIV ILLINOIS, HUMANA HOSP MICHAEL REESE, DIV ENDOCRINOL, CHICAGO, IL 60616 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1993年 / 77卷 / 01期

关键词：

D O I：

10.1210/jc.77.1.183

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macroadenoma was treated preoperatively with octreotide to attain euthyroidal status. Lectin chromatography, performed on her immunopurified serum TSH obtained at baseline and 1 week after 50 mug three times daily octreotide therapy, revealed a significant increase in ricin binding after octreotide. This result is consistent with increased amounts of TSH isoforms with more exposed galactose residues. Further clinical studies to elucidate the effects of pharmacological agents on serum TSH isoforms and TSH bioactivity are needed.

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页码：183 / 187

页数：5

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