B-50 (GAP-43) IN THE RAT SPINAL-CORD CAUDAL TO HEMISECTION - LACK OF INTRASPINAL SPROUTING BY DORSAL-ROOT AXONS

被引：19

作者：

NACIMIENTO, W

SAPPOK, T

BROOK, GA

TOTH, L

OESTREICHER, AB

GISPEN, WH

NOTH, J

KREUTZBERG, GW

机构：

[1] ALBERT SZENT GYORGYI MED UNIV,DEPT MED CHEM,H-6701 SZEGED,HUNGARY

[2] UNIV UTRECHT,RUDOLF MAGNUS INST,UTRECHT,NETHERLANDS

[3] MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,W-8033 MARTINSRIED,GERMANY

来源：

NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期

关键词：

SPROUTING; DORSAL COLUMNS; SYNAPTIC PLASTICITY; DEGENERATION; REGENERATION; PYRAMIDAL TRACT; SPINAL CORD INJURY;

D O I：

10.1016/0304-3940(95)11707-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The controversial hypothesis that intraspinal sprouting by dorsal root axons promotes reinnervation of partially denervated neurons caudal to a low thoracic cord hemisection was re-investigated in rats using quantitative immunohistochemical analysis of the neural specific growth-associated protein B-50 (GAP-43) at postoperative survival times of 3, 10, 21, 42, and 90 days. The lack of increase in B-50-immunoreactivity in all segments below the hemisection at all survival times does not support the concept of intraspinal sprouting following the removal of supraspinal descending pathways.

引用

页码：13 / 16

页数：4

共 25 条

[1] RELATIONSHIP OF AFFERENTATION WITH SOMA SIZE OF NUCLEUS GRACILIS NEURONS AFTER BILATERAL DORSAL COLUMN LESION IN THE RAT [J].