A SINGLE-POT SYNTHESIS OF 1,1,2-TRISUBSTITUTED 1,2-DIHYDRONAPHTHALENES IN HIGH ENANTIOMERIC PURITY

被引：14

作者：

MOKHALLALATI, MK ^{[1
]}

MURALIDHARAN, KR ^{[1
]}

PRIDGEN, LN ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT SYNTHET CHEM,KING OF PRUSSIA,PA 19406

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)73330-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective addition of Grignard reagents to nonracemic 2-(1-naphthyl)-4-(4R)-phenyl-1,3-oxazolidines (1) followed by electrophilic trapping of the azaenolate is described. This tandem addition was performed in a single flask producing, 1,1,2-trisubstituted 1,2-dihydronaphthalenes 7 in excellent yields and high enantioselectivities.

引用

页码：4267 / 4270

页数：4

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