CHOLINERGIC SIGNALS TO AND FROM THE IMMUNE-SYSTEM

被引：28

作者：

RINNER, I

FELSNER, P

FALUS, A

SKREINER, E

KUKULANSKY, T

GLOBERSON, A

HIROKAWA, K

SCHAUENSTEIN, K

机构：

[1] GRAZ UNIV,SCH MED,DEPT GEN & EXPTL PATHOL,A-8010 GRAZ,AUSTRIA

[2] SEMMELWEIS UNIV MED,DEPT BIOL,H-1445 BUDAPEST,HUNGARY

[3] WEIZMANN INST SCI,DEPT CELL BIOL,IL-76100 REHOVOT,ISRAEL

[4] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT IMMUNOPATHOL,TOKYO,JAPAN

来源：

IMMUNOLOGY LETTERS | 1995年 / 44卷 / 2-3期

关键词：

IMMUNE-NEUROENDOCRINE INTERACTION; ADRENERGIC; CHOLINERGIC SIGNAL; IMMUNE FUNCTION; APOPTOSIS; THYMUS EPITHELIUM;

D O I：

10.1016/0165-2478(94)00220-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article reviews recent data from our laboratory towards the impact of the autonomous nervous system on mutual interactions between the immune system and the central nervous system. Using a pharmacological approach in rats it is shown that shifts in the adrenergic/cholinergic balance in vivo affect in vitro functions of the non-specific and specific immune system, whereby adrenergic and cholinergic stimulation in general have opposite effects. A high degree of integration appears to exist between cells of the immune system with the cholinergic system. Lymphocytes were found to react to acetylcholine, but are also able to produce and to degradate this neurotransmitter. In addition, changes in the cholinergic tonus were found to affect immune signaling to the brain and to protect thymocytes from apoptosis, possibly via a direct effect on thymic epithelial cells.

引用

页码：217 / 220

页数：4

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