DEPOSITION OF ULTRAFINE AEROSOLS IN A HUMAN ORAL CAST

This paper reports experimental measurements of the total deposition of ultrafine aerosols in a human oral airway cast. A clear polyester resin cast of the upper airways of a normal human adult, including the nasal airways, oral cavity, tongue, nasopharynx, and larynx, was made from a postmortem solid cast. Measured pressure drop in the oral airway was slightly lower than in the nasal airway. The measured oral flow resistance was similar to the values reported for human volunteers breathing through the mouth at rest and for spontaneously opening of the mouth. Aerosol deposition data in the cast for monodisperse NaCl aerosols between 0.2 and 0.005 μm in diameter deposited in the cast were obtained for inspiratory and expiratory flow rates of 4, 20, and 40 L/min. Deposition efficiency increased with decreasing particle size and flow rate indicating that turbulent diffusion was the dominant mechanism for deposition. Higher deposition efficiency was observed for inspiratory flow in the oral airway than for expiratory flow. Oral deposition and nasal deposition for inspiratory flow were similar, but oral deposition was lower for expiratory flow. Deposition efficiency can be expressed as a function of the flow rate and diffusion coefficient of the particle. © 1990 Elseiver Science Publishing Co., Inc.