A SUPERFAMILY OF DROSOPHILA-SATELLITE RELATED (SR) DNA REPEATS RESTRICTED TO THE X-CHROMOSOME EUCHROMATIN

被引：53

作者：

DIBARTOLOMEIS, SM

TARTOF, KD

JACKSON, FR

机构：

[1] WORCESTER FDN EXPTL BIOL INC,NEUROBIOL GRP,SHREWSBURY,MA 01545

[2] INST CANC RES,FOX CHASE CANC CTR,PHILADELPHIA,PA 19111

来源：

NUCLEIC ACIDS RESEARCH | 1992年 / 20卷 / 05期

关键词：

D O I：

10.1093/nar/20.5.1113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1.688 g/cm3 class of Drosophila satellite DNA is predominantly localized to the centromeric heterochromatin of the X chromosome. We report here the existence of 1.688 satellite related (SR) DNA arrays present at numerous locations throughout the euchromatic portion of the X. Unlike their heterochromatic counterparts, euchromatic SRs consist of a small number of repeating units (usually 2-4), each of which is 63-81% identical to the 359-bp monomer of the 1.688 satellite. Although it appears that SR DNA arrays are not transcribed, in at least two cases, they are located adjacent to transcriptionally active genes. SR sequences also have significant similarity to a previously described Drosophila middle repeat found almost exclusively in the X euchromatin. It seems likely that these X linked sequences are required for sex chromosome specific functions.

引用

页码：1113 / 1116

页数：4

共 18 条

[1] BUFFER GRADIENT GELS AND S-35 LABEL AS AN AID TO RAPID DNA-SEQUENCE DETERMINATION
BIGGIN, MD
GIBSON, TJ
HONG, GF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13): : 3963 - 3965
[2] DIFFERENT REGIONS OF A COMPLEX SATELLITE DNA VARY IN SIZE AND SEQUENCE OF THE REPEATING UNIT
CARLSON, M
BRUTLAG, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1979, 135 (02) : 483 - 500
[3] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[4] DIBARTOLOMEIS SM, UNPUB DROSOPHILA DUS
[5] ENGELS WR, 1986, FOCUS, V8, P6
[6] SEQUENCE AND SEQUENCE VARIATION WITHIN THE 1.688 G-CM3 SATELLITE DNA OF DROSOPHILA-MELANOGASTER
HSIEH, T
BRUTLAG, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1979, 135 (02) : 465 - 481
[7] THE MALELESS PROTEIN ASSOCIATES WITH THE X-CHROMOSOME TO REGULATE DOSAGE COMPENSATION IN DROSOPHILA
KURODA, MI
KERNAN, MJ
KREBER, R
GANETZKY, B
BAKER, BS
[J]. CELL, 1991, 66 (05) : 935 - 947
[8] PROTEIN-D1 PREFERENTIALLY BINDS A+T-RICH DNA INVITRO AND IS A COMPONENT OF DROSOPHILA-MELANOGASTER NUCLEOSOMES CONTAINING A+T-RICH SATELLITE DNA
LEVINGER, L
VARSHAVSKY, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (23): : 7152 - 7156
[9] ROLE OF X-CHROMOSOME INACTIVATION DURING SPERMATOGENESIS
LIFSCHYTZ, E
LINDSLEY, DL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (01) : 182 - +
[10] Lohe A, 1988, HETEROCHROMATIN MOL, P148

← 1 2 →