DELAYED NEUROTOXIC EFFECT OF SARIN IN MICE AFTER REPEATED INHALATION EXPOSURE

被引：37

作者：

HUSAIN, K ^{[1
]}

VIJAYARAGHAVAN, R ^{[1
]}

PANT, SC ^{[1
]}

RAZA, SK ^{[1
]}

PANDEY, KS ^{[1
]}

机构：

[1] DEF RES & DEV ESTAB,DIV SYNTHET CHEM,GWALIOR 474002,INDIA

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1993年 / 13卷 / 02期

关键词：

DELAYED NEUROTOXICITY; SARIN; INHALATION EXPOSURE; MICE; NTE; BRAIN; SPINAL CORD; PLATELETS;

D O I：

10.1002/jat.2550130212

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Delayed neurotoxicity of sarin in mice after repeated inhalation exposure has been studied. Female mice exposed to atmospheric sarin (5 mg m-3 for 20 min) daily for 10 days developed muscular weakness of the limbs and slight ataxia on the 14th day after the start of the exposure. These changes were accompanied by significant inhibition of neurotoxic esterase (NTE) activity in the brain, spinal cord and platelets. Histopathology of the spinal cord of exposed animals showed focal axonal degeneration. These changes were comparatively less than in animals treated with the neurotoxic organophosphate, mipafox. Results from this study indicate that sarin may induce delayed neurotoxic effects in mice following repeated inhalation exposure.

引用

页码：143 / 145

页数：3

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