VITAMIN-E ATTENUATES THE TOXIC EFFECTS OF 6-HYDROXYDOPAMINE ON FREE-RADICAL SCAVENGING SYSTEMS IN RAT-BRAIN

被引：95

作者：

PERUMAL, AS ^{[1
]}

GOPAL, VB ^{[1
]}

TORDZRO, WK ^{[1
]}

COOPER, TB ^{[1
]}

CADET, JL ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, INST NEUROL, NEW YORK, NY 10032 USA

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 05期

关键词：

6-HYDROXYDOPAMINE; GLUTATHIONE; SUPEROXIDE DISMUTASE; VITAMIN-E; FREE RADICAL; PARKINSONS DISEASE;

D O I：

10.1016/0361-9230(92)90142-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were divided into the following four groups namely (a) sham-operated control, (b) 6-OHDA-treated, (c) sham-operated vitamin E-fed and (d) Vitamin E-fed treated with 6-OHDA. Total glutathione (GSH) and superoxide dismutase (SOD) were measured in brainstem (BS), striatum (ST), hippocampus, frontal cortex, and nucleus accumbens (N. Acc.). GSH and SOD levels were significantly decreased in all regions of 6-OHDA-treated rats compared to controls. Feeding of vitamin E resulted in a significant reduction of GSH in ST and N. Acc. but caused increases in SOD in BS, ST, and N. Acc. Pretreatment of rats with vitamin E caused significant attenuation of the effects of 6-OHDA on GSH and SOD in most of the brain regions. These results show that vitamin E can spare the scavenging systems from the injurious effects of 6-OHDA.

引用

页码：699 / 701

页数：3

共 26 条

[1] BRAIN PEROXIDASE AND CATALASE IN PARKINSON DISEASE
AMBANI, LM
VANWOERT, MH
MURPHY, S
[J]. ARCHIVES OF NEUROLOGY, 1975, 32 (02) : 114 - 118
[2] MEDICAL USES OF VITAMIN-E
BIERI, JG
CORASH, L
HUBBARD, VS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (18) : 1063 - 1071
[3] BREESE GR, 1970, J PHARMACOL EXP THER, V174, P413
[4] VITAMIN-E ATTENUATES THE TOXIC EFFECTS OF INTRASTRIATAL INJECTION OF 6-HYDROXYDOPAMINE (6-OHDA) IN RATS - BEHAVIORAL AND BIOCHEMICAL-EVIDENCE
CADET, JL
KATZ, M
JACKSONLEWIS, V
FAHN, S
[J]. BRAIN RESEARCH, 1989, 476 (01) : 10 - 15
[5] COHEN G, 1984, NEUROTOXICOLOGY, V5, P77
[6] COHEN G, 1974, J BIOL CHEM, V249, P2447
[7] COHEN G, 1976, J PHARMACOL EXP THER, V199, P336
[8] FREE-RADICAL-MEDIATED FRAGMENTATION OF MONOAMINE-OXIDASE IN THE MITOCHONDRIAL-MEMBRANE - ROLES FOR LIPID RADICALS
DEAN, RT
THOMAS, SM
GARNER, A
[J]. BIOCHEMICAL JOURNAL, 1986, 240 (02) : 489 - 494
[9] DEAN RT, 1985, INTRACELLULAR PROTEI, P341
[10] BASAL LIPID-PEROXIDATION IN SUBSTANTIA NIGRA IS INCREASED IN PARKINSONS-DISEASE
DEXTER, DT
CARTER, CJ
WELLS, FR
JAVOYAGID, F
AGID, Y
LEES, A
JENNER, P
MARSDEN, CD
[J]. JOURNAL OF NEUROCHEMISTRY, 1989, 52 (02) : 381 - 389

← 1 2 3 →